Authors: Senchak, Andrew J.; Sato, Aileen K.; Vazquez, Raymond; Keller, Christopher E.; Cable, Benjamin B.

Source: Comparative Medicine, Volume 57, Number 6, December 2007 , pp. 594-596(3)

Publisher: American Association for Laboratory Animal Science

Abstract:

Unwanted scar tissue after surgical procedures remains a central problem in medicine. Nowhere is this problem more evident than within the pediatric airway, where excess scarring, termed subglottic stenosis, can compromise breathing. Recent advances in molecular biology have focused on ways to decrease scar formation through understanding of the wound repair process. Transforming growth factor β (TFGβ) plays a central role in this pathway. Ferrets serve as an ideal model for the pediatric airway, and reproduction of subglottic stenosis in ferrets is possible. However, ferret cytokine profiles have not been established. In this study, we characterized the presence and nucleotide sequence of the TGFβ1 and 2 genes in ferrets by using total RNA isolated from airways. Amino acid sequence homology between human and ferret was determined to be 96.6% for TGFβ1 and 99.3% for TGFβ2. Given the nearly total homology between TGFβs of ferret and human origin, the ferret may serve as an ideal model for future molecular studies.

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Document Type: Miscellaneous

Publication date: 2007-12-01

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• Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.
  
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