Authors: Xie, Xiaobin; Ramkumar, Vickram; Toth, Linda A.

Source: Comparative Medicine, Volume 57, Number 6, December 2007 , pp. 538-545(8)

Publisher: American Association for Laboratory Animal Science

Abstract:

This review will examine how dopamine, a monoamine neurotransmitter, and adenosine, a neuromodulator, regulate behavioral activation, primarily as reflected by locomotor activity, in rodents. Complex interactions among 2 major types of adenosine receptors (A₁AR and A_2AAR) and 2 dopamine receptors (D₁R and D₂R) occur due to physical interactions that alter their ligand-binding properties and subsequent effects on common postreceptor signaling molecules. The output from these interactions in striatum modulates neurotransmission and subsequently influences spontaneous locomotor activity. Caffeine is a nonselective adenosine receptor antagonist that blocks 2 major types of adenosine receptors, A₁AR and A_2AAR, in the brain. Pharmacologic manipulation of these receptors with drugs such as caffeine offers potential therapeutic benefit for treatment of Parkinson disease.

References: 77 references open in new window

Articles that cite this article?

Document Type: Miscellaneous

Publication date: 2007-12-01

More about this publication?

• Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.
  
  Attention Members: To access the full text of the articles, be sure you are logged in to the AALAS website.
• Editorial Board
• Information for Authors
• Submit a Paper
• Subscribe to this Title
• Membership Information
• Information for Advertisers
• For issues prior to 1998
• Institutional Subscription Activation
• ingentaconnect is not responsible for the content or availability of external websites

Related content

• In this: publication
• By this: publisher
• In this Subject: Biology/Life Sciences ,  Zoology ,  Veterinary Medicine
• By this author: Xie, Xiaobin ;  Ramkumar, Vickram ;  Toth, Linda A.

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers