Anemia and Antibodies to the 19-kDa Fragment of MSP1 During Plasmodium falciparum Infection in Aotus Monkeys
Authors: Gozalo, Alfonso S; Lucas, Carmen M; Qin, Jing; Hall, Ted B; Magill, Alan J
Source: Comparative Medicine, Volume 57, Number 4, August 2007 , pp. 396-401(6)
Abstract:To determine whether antibodies to the 19-kDa fragment of merozoite surface protein 1 (MSP119) help to control blood-stage Plasmodium falciparum infection, we performed a rechallenge experiment of previously infected Aotus monkeys. Monkeys previously exposed to the FVO strain of P. falciparum that did or did not develop high antibody titers to MSP119 and malaria-naïve monkeys were challenged with erythrocytes infected with the same strain. Prepatent periods were prolonged in previously infected monkeys compared with malaria-naïve monkeys. Previously infected monkeys with preexisting anti-MSP119 antibodies showed low peak parasitemias that cleared spontaneously. Previously infected monkeys that had no or low levels of pre-existing anti-MSP119 antibodies also showed low peak parasitemias, but because of low hematocrits, all of these animals required treatment with mefloquine. All previously malaria-naïve animals were treated because of high parasitemias. The results of this study suggest that antibody to the 19-kDa carboxy-terminal fragment of MSP1 plays a role in preventing the development of anemia, an important complication often associated with malaria.
Document Type: Miscellaneous
Publication date: August 1, 2007
- Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.
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