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Open Access The Ex Vivo Pig Eye as a Replacement Model for Laser Safety Testing

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The purpose of this study was to evaluate the viability of ex vivo pig eyes as a replacement model for in vivo testing in the establishment of laser eye safety standards. Previous studies of pulsed energy absorption at 3.8 m were performed using rhesus monkey cornea at pulse durations two orders of magnitude shorter than the 8-s pulses used in the current study. Ex vivo pig eyes were exposed to laser pulses of various energies and then evaluated to establish the statistical threshold for corneal damage. Tissue analysis (histologic evaluation) was used to determine the extent of damage to the cornea. These results can be used in the establishment of safety standards for laser use; our findings also suggest that ex vivo pig eyes are suitable models for this purpose.

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Document Type: Research Article

Affiliations: 1: Uniformed Services University of the Health Sciences, Department of Preventive Medicine and Biometrics, Bethesda, Maryland 2: Colorado State University, Department of Environmental and Radiological Health Sciences, Fort Collins Colorado

Publication date: 2005-12-01

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  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

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