Cardiomyopathy in Captive Owl Monkeys (Aotus nancymae)
Abstract:Dilated cardiomyopathy (DCM) was identified histopathologically in a colony of owl monkeys (Aotus nancymae) over a 15-year period. We characterized the incidence of cardiac disease echocardiographically in the colony over a 14-month period. Of 77 monkeys, 21 had systolic myocardial failure, and postmortem examination confirmed the antemortem diagnosis of DCM in eight animals. Monkeys with a questionable diagnosis at the first examination demonstrated progression of disease with time. Left ventricular end-systolic cross-sectional area and left ventricular fractional area change were the indices that most reliably discriminated between normal and diseased animals. Serum cardiac troponin I concentrations were below detectable limits in normal and diseased monkeys. The apparent high prevalence of disease in this colony precluded establishment of reference intervals for Aotus nancymae. Our study provides the first comprehensive echocardiographic evaluation of owl monkeys with cardiomyopathy.
Document Type: Research Article
Affiliations: 1: Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853 2: Division of Veterinary Medicine, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910 3: Department of Pathology, Naval Medical Research Center, Silver Spring, MD 20910 4: Department of Epidemiology and Diagnostic Sciences, S1074 Schurman Hall, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853
Publication date: April 1, 2005
Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.
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