Open Access Clinical Patent Ductus Arteriosus in Adult Genetically Epilepsy-Prone Rats

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Abstract:

Persistent patent ductus arteriosus (PDA) and clinically silent PDAs are relatively common congenital cardiac defects in humans. We report here the occurrence of symptomatic PDA in adults from a colony of genetically epilepsy-prone rats (GEPRs). Affected rats displayed severe ventral edema. Echocardiography revealed PDA in several animals. Necropsy findings included cardiomegaly, hepatic hyperemia and centrilobular necrosis indicative of passive congestion, and vascular changes consistent with pulmonary hypertension. All affected rats were descendants of one of two brother–sister breeding pairs established from a single litter in April 2000. Clinically silent PDAs were also detected in the colony. Histological examination of the ligamentum arteriosus showed normal vascular tissue in asymptomatic GEPR and Sprague-Dawley rats. PDAs are likely to have a genetic component in the GEPR colony and may provide a novel model for the study of pathogenesis and therapy of this condition.

Document Type: Case Report

Affiliations: 1: Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, 1600 E. Rollins Road, University of Missouri, Columbia, Missouri 65211 2: Department of Pharmacology and Division of Laboratory Animal Medicine, Southern Illinois University School of Medicine, Springfield, Illinois 62794 3: Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois 62794 4: Research Animal Diagnostic Laboratory, Department of Veterinary Pathobiology, College of Veterinary Medicine, 1600 E. Rollins Road, University of Missouri, Columbia, Missouri 65211

Publication date: February 1, 2005

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  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

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