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Open Access Oral Papillomas and Papilliform Lesions in Rhesus Macaques (Macaca mulatta)

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Oral papillomas in two male rhesus macaques that were diagnosed morphologically as filiform and squamous types are described. Two additional macaques had oral papilliform lesions consistent histologically with papillary hyperplasia. Immunohistochemistry, along with electron microscopy and PCR assays, failed to demonstrate evidence of papillomavirus in any of the tumors; however, such results are often lacking when suspect oral lesions in humans and other species are assessed. Other potential causes of the papillary masses include chronic irritation and perhaps a genetic susceptibility. Benign tumors of the oral epithelium in macaques have not been reported previously; they appear to be rare and of variable clinical significance.

Document Type: Case Report

Affiliations: 1: Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139 2: New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772 3: Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, Zoological Society of San Diego, CRES, San Diego, California 92101-1635

Publication date: 2005-02-01

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  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

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