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Open Access Gender Differences in Deep Venous Thrombosis in a Rat Model: A Preliminary Study

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Abstract:

The purpose of this study was to determine whether gender differences have an effect on inflammation and thrombosis in a rat model of venous thrombosis. A thrombus was created in mature female (n = 12) and male (n = 12) Sprague Dawley rats (Rattus norvegicus) by ligating the inferior vena cava (IVC). The IVC containing the thrombus was harvested at 1 and 3 days postligation, weighed, measured, and submitted for immunohistochemical analysis. In addition, hematology was performed at selected time points. There were no statistically significant differences in thrombus mass (mean ± 1 standard deviation) between female and male rats at 1 (683 ± 47.7 × 10−4 versus 660 ± 112.0 × 10−4 g/cm) or 3 (683 ± 83.3 × 10−4 versus 580 ± 86.0 × 10−4 g/cm) days post-ligation. Females had significantly more platelets than did males on day 1 (741 ± 37.2 versus 523 ± 55.1 K/L, P < 0.01). Day 3 males showed significant increases in vein wall neutrophils (18.0 ± 2.30 versus 11.2 ± 1.38, P < 0.05), ED-1-positive monocytes (54.4 ± 16.0 versus 18.7 ± 5.63, P < 0.05), and circulating white blood cells (15.4 ± 0.947 × 103 versus 10.9 ± 0.714 × 10−3/L, P < 0.01) at post-thrombosis when compared with females. We conclude that although female rats had greater thrombus mass, the male rats demonstrated more inflammatory cells in circulation and in their vein walls. This finding suggests that inflammation plays a role in thrombus resolution.

Document Type: Research Article

Affiliations: 1: Jobst Vascular Research Laboratories, Section of Vascular Surgery, University of Michigan Medical School, Ann Arbor, Michigan 48109, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan 48824 2: Jobst Vascular Research Laboratories, Section of Vascular Surgery, University of Michigan Medical School, Ann Arbor, Michigan 48109 3: Jobst Vascular Research Laboratories, Section of Vascular Surgery, Unit for Laboratory Animal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109

Publication date: February 1, 2005

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  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

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