Open Access Comparative Study of Lung Cytologic Features in Normal Rhesus (Macaca mulatta), Cynomolgus (Macaca fasicularis), and African Green (Chlorocebus aethiops) Nonhuman Primates by Use of Bronchoscopy

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Abstract:

Invasive bronchoscopy and bronchoaveolar lavage (BAL) fluid collection represents an important tool in studies of the respiratory system of nonhuman primates. Bronchoscopy and BAL fluid collection was performed on groups of rhesus (Macaca mulatta) and cynomolgus (Macaca fasicularis) macaques and African green monkeys (Chlorocebus aethiops), and the resulting comparative lavage cytologic features are described. Analysis of the BAL fluid did not reveal significant differences among species with respect to total cells recovered or differential cellular composition. This description of the method used to lavage the nonhuman primates and the resulting lung cytologic findings provide important comparative data for three species commonly used in biomedical research.

Document Type: Research Article

Affiliations: 1: Division of Veterinary Medicine, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 20702-5011 2: Division of Toxinology and Aerobiology, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 20702-5011

Publication date: August 1, 2004

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  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

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