The Genetic Immunodeficiency Disease, Leukocyte Adhesion Deficiency, in Humans, Dogs, Cattle, and Mice
Abstract:This review highlights the genotype-phenotype relationship of the genetic immunodeficiency disease leukocyte adhesion deficiency (LAD) in humans, dogs, cattle, and mice, and provides assessment of the opportunities that each animal species provides in the understanding of leukocyte biology and in developing new therapeutic approaches to LAD in humans. This comparison is important since animal models of genetic diseases in humans provide the opportunity to test new therapeutic approaches in an appropriate, disease-specific model. The success of this approach is dependent on the relationship of the phenotype in the animal to the phenotype of the disease in humans.
Document Type: Research Article
Affiliations: 1: Experimental Transplantation and Immunology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 2: Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011 3: Section of Leukocyte Biology, Department of Pediatrics, Immunology and Medicine, Baylor College of Medicine, Houston, Texas 77030 4: Virus and Prion Disease of Livestock Research Unit, National Animal Disease Center-USDA-ARS, Ames, Iowa 50010 5: Office of Research Services, Division of Veterinary Resources, National Institutes of Health, Bethesda, Maryland 20892
Publication date: 2004-08-01
Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.
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