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Open Access Fine Mapping of the Circling (cir) Gene on the Distal Portion of Mouse Chromosome 9

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Circling mice manifest profound deafness, head-tossing, and bi-directional circling behavior, which they inherit in autosomal recessive manner. Histologic examination of the inner ear reveals abnormalities of the region around the organ of Corti, spiral ganglion neurons, and outer hair cells. A genetic linkage map was constructed for an intraspecific backcross between cir and C57BL/6J mice. The cir gene was mapped to a region between D9Mit116/D9Mit15 and D9Mit38 on mouse chromosome (Chr) 9. Estimated distances between cir and D9Mit116, and between cir and D9Mit38 were 0.70 ± 0.40 and 0.23 ± 0.23 cM, respectively. Order of the markers was defined as follows: centromere - D9Mit182 - D9Mit51/D9Mit79/ D9Mit310 - D9Mit212/D9Mit184 - D9Mit116/D9Mit15 - cir - D9Mit38 - D9Mit20 - D9Mit243 - D9Mit16 - D9Mit55/D9Mit125 - D9Mit281. On the basis of genetic mapping, we constructed a yeast artificial chromosome (YAC) contig across the cir region. The cir gene is located between the lactotransferrin (ltf) and microtubule-associated protein (map4) genes. The distal portion of mouse Chr 9 encompassing the cir region is homologous with human chromosome 3p21, which contains the Deafness, form B: Autosomal Recessive Deafness (DFNB6) locus. Therefore, the circling mouse is a potential animal model for DFNB6 deafness in humans.

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Document Type: Research Article

Affiliations: 1: Catholic Research Institutes of Medical Science, Catholic Medical College, 505 Banpo-Dong, Seocho-Ku, Seoul 137-701, Korea 2: Department of Laboratory Animal Sciences, College of Medicine, Hanyang University, SEOUL 100-799, Korea 3: Department of Medical Genetics and Experimental Animal Center, College of Medicine, Hallym University, Chunchon 200-702, Korea 4: Eulji University, Seoul, Korea 5: Department of Psychology, Korea University, Seoul, Korea 6: Sungkyunkwan University, Seoul, 135-710, Korea 7: Biological Resource Center, Korea Research Institute of Bioscience and Biotechnology, Oun-dong 52, Yusong-ku, Daejeon 305-333, Republic of Korea

Publication date: 2003-12-01

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  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

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