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Open Access Zoonoses of Occupational Health Importance in Contemporary Laboratory Animal Research

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In contemporary laboratory animal facilities, workplace exposure to zoonotic pathogens, agents transmitted to humans from vertebrate animals or their tissues, is an occupational hazard. The primary (e.g., macaques, pigs, dogs, rabbits, mice, and rats) and secondary species (e.g., sheep, goats, cats, ferrets, and pigeons) of animals commonly used in biomedical research, as classified by the American College of Laboratory Animal Medicine, are established or potential hosts for a large number of zoonotic agents. Diseases included in this review are principally those wherein a risk to biomedical facility personnel has been documented by published reports of human cases in laboratory animal research settings, or under reasonably similar circumstances. Diseases are listed alphabetically, and each section includes information about clinical disease, transmission, occurrence, and prevention in animal reservoir species and humans. Our goal is to provide a resource for veterinarians, health-care professionals, technical staff, and administrators that will assist in the design and on-going evaluation of institutional occupational health and safety programs.

Document Type: Research Article

Affiliations: 1: Unit for Laboratory Medicine, School of Medicine, University of Michigan, 48109-0614 2: Department of Comparative Medicine, School of Medicine, University of Washington, 62794-9611 3: Fred Hutchinson Cancer Research Center and Department of Comparative Medicine, School of Medicine and Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, 98109-1024 4: Department of Comparative Medicine, School of Medicine and Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, 98195-7190

Publication date: December 1, 2003

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  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

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