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Open Access XY Female Marmoset (Callithrix jacchus)

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Abstract:

A marmoset (Callithrix jacchus) with atypical external genitalia was phenotypically and genetically characterized. Testosterone concentration correlated with that of female marmosets. Externally, there was only one opening for the urethra. Internal genitalia were characteristic of those of female marmosets, and consisted of ovaries, with follicles in various developmental stages, and uterus. Microscopically, a normal vaginal structure was found. An XX/XY chimerism and high steroid hormone values are normally found in common marmosets. Genetic analysis was used for in vivo determination of sex. The Y-linked zinc finger protein gene (ZFY) last intron, and sex-determining region Y gene (SRY) exon were found by use of polymerase chain reaction and posterior sequencing analyses, indicating that this marmoset had Y-linked chromosome sequences. Normal SRY exons can, therefore, be associated with female internal sexual organs in marmosets; this may be the first XY female described in non-human primates.

Document Type: Research Article

Affiliations: 1: Laboratory Animal Science, GlaxoSmithkline, The Frythe, Welwyn, Herts, AL6 9AR, The Royal Veterinary College, Royal College Street, NW1 0TU, London, United Kingdom 2: Department of Pathology, GlaxoSmithKline, Park Road, Ware, Herts SG12 0DP, United Kingdom 3: Laboratory Animal Science, GlaxoSmithkline, The Frythe, Welwyn, Herts, AL6 9AR

Publication date: October 1, 2003

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  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

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