Liposome-Encapsulated Oxymorphone Hydrochloride Provides Prolonged Relief of Postsurgical Visceral Pain in Rats
Abstract:Adequate pain control is necessary for optimal postsurgical recovery and humane treatment of laboratory and companion animals. Opioid drugs are currently the most potent analgesic agents available in human and veterinary medicine. Long-acting formulations of opioid drugs confer several important advantages over standard pharmaceutical preparations, especially for use in animals. A long-acting formulation of oxymorphone hydrochloride was produced by encapsulation into liposomes. Liposome-encapsulated (LE) oxymorphone was tested in a rat model of visceral postoperative pain. Rats were given one subcutaneous injection of LE oxymorphone (1.2 or 1.6 mg/kg of body weight) or standard oxymorphone (0.3 mg/kg) at the time of intestinal transection or resection. A single administration of LE oxymorphone hydrochloride was as effective for relief of postoperative pain in rats (P = 0.18), as were multiple (q4 h or q8 h) injections of 0.3 mg/kg of the standard pharmaceutical preparation. The rats given LE oxymorphone prior to intestinal resection also had significantly higher body weight at three and seven days after surgery than did rats that were given standard oxymorphone. In conclusion, LE oxymorphone was effective in treating visceral pain associated with intestinal surgery in rats. On the basis of body weight gain, rats treated with LE oxymorphone had improved recovery outcome, compared with rats treated with repeated injections of standard oxymorphone.
Document Type: Research Article
Affiliations: 1: Research Animal Resource Center, University of Wisconsin-Madison, 1710 University Ave. Madison, Wisconsin 53705-4098 2: School of Veterinary Medicine, University of Wisconsin-Madison, 1710 University Ave. Madison, Wisconsin 53705-4098 3: Laboratory Animal Services, 414 E. Clark St., Lee Medical Bldg., University of South Dakota, Vermillion South Dakota 57069 4: School of Pharmacy, University of Wisconsin-Madison, 1710 University Ave. Madison, Wisconsin 53705-4098 5: Department of Nutritional Sciences, University of Wisconsin-Madison, 1710 University Ave. Madison, Wisconsin 53705-4098
Publication date: 2003-06-01
Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.
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