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Open Access Vascular Leak Syndrome of Sprague-Dawley Rats in a Mandibular Distraction Osteogenesis Study

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Vascular leak syndrome (VLS) is a common and often fatal sequela of multiple bone traumas, and of infectious, toxic, and allergic insults in human patients. Although an animal model for VLS has not been fully established, rats have shown sensitivity to the syndrome that approximates that of the human population. We describe cases of VLS in three-month-old adult and one-month-old Sprague-Dawley rats in an osteogenesis study aimed at optimizing correction of bone hypoplasias and other craniofacial deformities in children, using a mandibular distraction device. In the study reported here, VLS was diagnosed in 46% of the rats that were necropsied after dying or being euthanized early, subsequent to mandibular osteotomy, a procedure that involves minimal bone trauma. The gross and histologic findings, as well as the clinical course of VLS in the rats of the osteogenesis study, were similar to those of documented human cases. Hence, the rat may be a useful animal model to help characterize the physiologic and molecular events that accompany this syndrome.

Document Type: Research Article

Affiliations: 1: Department of Comparative Medicine, University of Washington, 1959 North East Pacific Avenue, Box 357190, Seattle, Washington 98195 2: Department of Orthodontics, University of Washington, 1959 North East Pacific Avenue, Box 357446, Seattle, Washington 98195

Publication date: April 1, 2003

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  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

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