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Open Access Cryptosporidiosis Associated with Emaciation and Proliferative Gastritis in a Laboratory-Reared South African Clawed Frog (Xenopus laevis)

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A 2-year-old emaciated female South African clawed frog (Xenopus laevis) was euthanized because of chronic weight loss. At necropsy, there was no evidence of bacterial, fungal or viral disease; however, the histopathologic findings indicated a proliferative gastritis and the presence of numerous cryptosporidial stages throughout the intestinal tract. Crytosporidial oocysts were present in the water taken from the aquarium housing the infected frog and were likely shed by the sick frog; however, the exact source of the oocysts could not be identified. Water samples from other frog aquaria in the facility did not contain cryptosporidial oocysts. Some Cryptosporidium species are important zoonotic pathogens and, to our knowledge, this is the first report of disease associated with Cryptosporidium infection in a laboratory Xenopus laevis.

Document Type: Research Article

Affiliations: 1: Department of Comparative Medicine, Stanford University School of Medicine, RAF 1, Quad 7, Bldg. 330, Stanford, California 94305 2: USDA, ARS, ANRI, Animal Waste Pathogen Laboratory, Beltsville, Maryland, 20705

Publication date: 2003-02-01

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  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

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