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Open Access Species Characterization of Plasma Nitrite/Nitrate (NOx) Concentration

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Experiments were designed to detect and determine differences between nitrite/nitrate concentration ([NOx]) in plasma across 15 species selected from seven classes of vertebrates. Blood collected in syringes was placed immediately into ethylenediaminetetraacetic acid (EDTA)-containing tubes and was centrifuged. Plasma [NOx] was determined by measurement of chemiluminescence. Across classes of vertebrates, baseline plasma [NOx] ranged from 0.6 to 171.3 nmol/ml. Mean ± SD plasma [NOx] was highest in a fresh-water, jawless fish (lamprey, 95.5 ± 9.1 nmol/ml) and lowest in a saltwater cartilaginous fish (skates, 1.1 ± 0.4 nmol/ml). Both amphibians tested had a wide range in plasma [NOx], which was explained partly by temporal changes during the year. Within the mammalian class, plasma [NOx] ranged from 3.8 to 43.2 nmol/ml. Results of this study indicate that NOx is detectable in plasma of all classes of vertebrates and that baseline concentration varies among species.

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Document Type: Research Article

Affiliations: 1: Capillary Physiology and Microcirculation Research Laboratory, S336 Sinclair School of Nursing, University of Missouri–Columbia, Columbia, Missouri 65211-4120 2: Radiology Research Laboratory, Department of Radiology, 2-Alfred, CAVBI, 200 First St. SW, Mayo Clinic and Foundation, Rochester, Minnesota 55905 3: Department of Pathology and Anatomical Sciences, M312 Medical Sciences Building, University of Missouri–Columbia, Columbia, Missouri 65212 4: Departments of Surgery, Physiology & Biophysics, 4-57 Medical Sciences Building, 200 First St. SW, Mayo Clinic and Foundation, Rochester, Minnesota 55905

Publication date: 2003-02-01

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  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

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