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Open Access Bordetella bronchiseptica Infection of Rats and Mice

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Bordetella bronchiseptica has long been associated with respiratory tract infections in laboratory research, foodproducing, companion, and wildlife animal species. Its range of distribution also may include humans and contaminated inanimate environmental sources. Natural diseases due to B. bronchiseptica infections in laboratory rats and mice were described before many of the major pathogens of these hosts were discovered. To our knowledge, there are no recent reports of natural disease due to B. bronchiseptica in these species; as a result, some have questioned its role as a natural pathogen in murine hosts. We reviewed occurrence of natural B. bronchiseptica infections and present information gained from recent experimental infection studies in murine hosts. We also discuss the potential impact of natural B. bronchiseptica infections on research and methods of control.

Document Type: Research Article

Affiliations: 1: Department of Comparative Medicine, The University of Tennessee, College of Veterinary Medicine, Knoxville, Tennessee 37996-4543 2: Pathology and Technical Services, Charles River Laboratories, Wilmington, Massachusetts 01887

Publication date: 2003-02-01

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  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

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