Open Access

Use of Perphenazine to Control Cannibalism in DBA/1 Mice

Authors: Carter, D. Bart1; Kennett, Mary J.2; Franklin, Craig L.3

Source: Comparative Medicine, Volume 52, Number 5, October 2002 , pp. 452-455(4)

Publisher: American Association for Laboratory Animal Science

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Maternal administration of perphenazine decreased the incidence of cannibalism in colonies of interferon-, interleukin (IL-4, IL-10, and IL-12) knockout mice of the DBA/1 and C57BL/6 background strains. This colony had high incidence of neonatal death due to cannibalism in approximately 50% of the pups. Perphenazine was administered to the dams in the drinking water, beginning on the day before or the morning of parturition. The medicated water was supplied at two dosages: 0.5 mg/ml and 0.025 mg/ml, resulting in a dosage of 4 mg/kg of body weight and 2 mg/kg, respectively, to the dams. Dams that were treated with perphenazine weaned 76.4% of their pups, compared with non-treated dams that weaned only 59.4% of their pups. Timing of the administration of perphenazine did not have a significant impact on efficacy; also, both doses were equally effective at preventing cannibalism. These findings indicate that perphenazine can modify poor maternal behavior such as cannibalism, resulting in more efficient production of valuable knockout mice.

Document Type: Research Article

Affiliations: 1: Department of Veterinary Pathobiology, Office of Animal Resources, University of Missouri Columbia, Missouri 65212 2: Department of Veterinary Science, Animal Resource Program, The Pennsylvania State University, University Park, Pennsylvania 16802 3: Department of Veterinary Pathobiology, Research Animal Diagnostic Laboratory, University of Missouri Columbia, Missouri 65211

Publication date: October 1, 2002

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  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

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