Influence of Bedding Type on Mucosal Immune Responses
Abstract:The mucosal immune system interacts with the external environment. In the study reported here, we found that bedding materials can influence the intestinal immune responses of mice. We observed that mice housed on wood, compared with cotton bedding, had increased numbers of Peyer's patches (PP) visible under a dissecting microscope. In addition, culture of lymphoid organs revealed increased production of total and virus-specific IgA by PP and mesenteric lymph node (MLN) lymphocytes from mice housed on wood, compared with cotton bedding. However, bedding type did not influence serum virus-specific antibody responses. These observations indicate that bedding type influences the intestinal immune system and suggest that this issue should be considered by mucosal immunologists and personnel at animal care facilities.
Document Type: Research Article
Affiliations: 1: The Children's Hospital of Philadelphia, Division Immunologic and Infectious Diseases, 3615 Civic Center Boulevard, Philadelphia, Pennsylvania 19104; The University of Pennsylvania, Philadelphia, Pennsylvania 19104 2: The Children's Hospital of Philadelphia, Division Immunologic and Infectious Diseases, 3615 Civic Center Boulevard, Philadelphia, Pennsylvania 19104 3: The Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104
Publication date: 2002-10-01
Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.
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