Open Access Circling Mouse: Possible Animal Model for Deafness

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Mutant mice with abnormalities are potentially useful as models for studying human defects. Here we report a group of mice with abnormal behavioral patterns. A new spontaneous mutant mouse exhibited hyperactive behavior at about seven days of age, followed by tight circling behavior. Breeding studies suggest that this mutation is caused by a single gene defect inherited in an autosomal recessive manner. Consequently, this mutation is referred to as a circling (cir) mouse mutation with the gene symbol cir. Auditory test results identified clearly the hearing loss of the cir, compared with wild-type mice. Pathologic studies confirmed developmental defects in cochlea and spiral ganglions that were correlated to the abnormal behavior observed in the cir mice. Thus, cir mice may be useful as a model for studying inner ear abnormalities and deafness in humans.

Document Type: Research Article

Affiliations: 1: Laboratory Animal Center, and 6 Department of Dermatology, Catholic Research Institutes of Medical Science, Catholic Medical College, Seoul, 137-701, Korea 2: Department of ORL-HNS, Samsung Medical Center, Sungkyunkwan Univer- sity, Seoul, 135-710, Korea 3: College of Agriculture, Animal and Life Science, Kon-Kuk University, Seoul, 143-701, Korea 4: Deptartment of Psychology, Korea University, 5-Ka, Anam-dong Sungbuk-ku, Seoul, Korea 5: Department of Medi- cal Genetics, College of Medicine, Hallym University, Chunchon, 200-702, Korea

Publication date: December 1, 2001

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  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

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