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Open Access Variation of Serum α2-Macroglobulin Concentration in Healthy Rats and Rats Inoculated with Staphylococcus aureus or Subjected to Surgery

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Background and Purpose: The aim of the study reported here was to investigate variations in the serum concentration of α2 -macroglobulin (α2M) from healthy rats and rats inoculated with Staphylococcus aureus or subjected to surgery.

Methods: Concentration of α2M was measured by use of an enzyme-linked immunosorbent assay.

Results: Serum α 2M in healthy rats at intervals of 3 h, 1 day, and 1 week ranged from 17.5 to 38.0 (mean ± SD, 27.2 ± 6.6) g/ml, 15.8 to 48.2 (27.9 ±8.7) g/ml, and 17.2 to 39.6 (23.9 ±5.9) g/ml, respectively. Concentrations of α2M did not undergo significant variations within individuals or between rats. Serum α2M concentration increased at one day and peaked two days after inoculation with S. aureus or being subjected to surgery. Peak concentration was eight to 33 times pre-inoculation values after inoculation with S. aureus, four to 25 times pre-surgical values when rats were subjected to castration, and seven to 28 times pre-surgical values when rats were subjected to oophorohysterectomy, respectively.

Conclusions: Physiologic variation in the concentration of α2M in rats was not found. Induction of α2M in rats inoculated with S. aureus or subjected to surgery was documented.

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Document Type: Research Article

Affiliations: Laboratory of Immunology, College of Environmental Health, Azabu University, 1-17-71 Fuchinobe, Sagamihara, Kanagawa 229-8501, Japan

Publication date: 2001-08-01

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  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

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