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Open Access Gastric Dilatation Syndrome Associated with Chronic Nephropathy, Hypergastrinemia, and Gastritis in Mice Exposed to High Levels of Environmental Antigens

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Gastric dilatation (GD) has been observed in Tac:(SW)fBR surveillance mice, with mean age of 10 months, that are exposed to high levels of environmental antigens during routine exposure to dirty bedding. The aim of the study reported here was to determine whether GD was associated with other systemic conditions affecting mice. Three groups of nine animals including—surveillance mice not exposed to dirty bedding (control), surveillance mice without GD (NGD), and surveillance mice with GD (group GD)—had mean stomach weight with ingesta of 0.5 ± 0.02 g, 1.09 ± 0.07 g (P < 0.0001), and 2.54 ± 0.4 g (P < 0.0001), respectively. Mean serum creatinine concentration was significantly higher in GD (1.6 ± 0.25 mg/dl), compared with NGD (0.17 ± 0.22 mg/dl, P < 0.0001) and control (0.2 ± 0.16 mg/dl, P < 0.0001) mice. In addition, lesions consistent with severe chronic nephropathy and mild gastritis were common in GD, compared with NGD and control mice. Finally, serum amidated gastrin concentration was significantly high in GD (179.37 ± 53.86 p M, P < 0.03) and NGD (264.89 ± 115.89 p M, P < 0.009), compared with control (60.77 ± 8.39 p M) mice. Gastric dilatation syndrome is associated with chronic nephropathy, hypergastrinemia, and gastritis in surveillance mice exposed to high levels of environmental antigens.

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Document Type: Research Article

Affiliations: Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139

Publication date: 2001-06-01

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  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

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