The Obese Göttingen Minipig as a Model of the Metabolic Syndrome: Dietary Effects on Obesity, Insulin Sensitivity, and Growth Hormone Profile
Abstract:The objective of the study reported here was to induce obesity in the female Göttingen minipig to establish a model of the human metabolic syndrome. Nine- to ten-month-old female Göttingen minipigs received a high-fat high-energy (HFE) diet or a low-fat, low-energy (LFE) diet. The energy contents derived from fat were 55 and 13 %, respectively. After 5 weeks, animals were subjected to dual energy x-ray absorptiometry (DEXA) scanning, intravenous glucose tolerance testing (IVGTT), and 6-h growth hormone profile recording. After treatment, mean body weight of pigs of the LFE group was 21.0 ± 0.4 kg, and was 26.8 ± 0.2 kg in pigs of the HFE group (P < 0.0001). The DEXA scanning indicated that the fat content of the LFE group was 10.0 ± 1.2 % versus 15.2 ± 0.7 % in the HFE group (P < 0.003). Triglycerides concentration was significantly (P < 0.05) increased in pigs of the HFE group (0.24 ± 0.03 m M), compared with that in pigs of the LFE group (0.13 ± 0.04 m M). Preprandial plasma glucose and insulin concentrations were not affected, but insulin area under the curve during IVGTT was significantly high in the obese animals. Growth hormone (GH) secretion was low in both groups of pigs. The obese minipig shares some of the metabolic impairments seen in obese humans, and may thus serve as a model of the metabolic syndrome.
Document Type: Research Article
Affiliations: 1: Novo Nordisk A/S, Måløv, Denmark 2: The Royal Danish School of Pharmacy, Copenhagen, Denmark 3: University of Aarhus, Aarhus County Hospital, Department of Endocrinology, Aarhus, Denmark
Publication date: 2001-04-01
Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.
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