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Open Access Regional Variations in the Distributions of Small Intestinal Intraepithelial Lymphocytes (IELs) in BALB/c +/+, nu/+, and nu/nu Mice

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Regional variations in intraepithelial lymphocytes (IELs) in the small intestine were examined in BALB/c +/+, nu/+, and nu/ nu mice. The small intestine was obtained from 11- to 12-week-old mice and divided equally into three (proximal, middle, and distal) parts. The IELs were isolated from each part of the intestine, and the total numbers of IELs in nu/+ and nu/ nu mice were about a fifth of those in +/+ mice. Regional variations in the distribution of the IEL , but not the T-cell subset were found by use of flow cytometry in +/+ and nu/+ mice. On the other hand, such differences were not found in nu/ nu mice, suggesting that thymus-independent development of T cells is not different among regions. Different local expansion of thymus-dependent T cells may cause the regional variations seen in the distribution of T cell IELs in +/+ and nu/+ mice.

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Document Type: Research Article

Affiliations: Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo, Yayoi 1-1-1, Bunkyo-ku, Tokyo 113-8657, Japan

Publication date: 2001-04-01

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  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

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