Herpes B-Virus Specific-Pathogen-Free Breeding Colonies of Macaques (Macaca mulatta): Diagnostic Testing Before and After Elimination of the Infection
Methods: From 1990 through 1997, the B-virus Resource Laboratory screened macaques for B-virus, using ELISA or western immunoblot analysis. In 1993, we combined test results and housing histories to verify the seronegative status of one colony.
Results: Two groups of latently infected macaques were identified as to time and place of transmission. The infection was eradicated within 3 years (1990–1992), as judged by the absence of true positive seroreactivity in any screened macaques. New infections were not identified in four years of follow-up evaluation.
Conclusion: With rigorous surveillance, the SPF status of the colony was achieved and maintained.
Document Type: Research Article
Publication date: 2000-06-01
Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.
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