Experimental Models of Peripheral Neuropathies
Methods: Genetic modifications in mice and rats, similar to those seen in humans, along with animal models of specific gene defects are presented and discussed.
Results and Conclusion: Chemotherapeutic agents administered to affected animals mimic the dose-dependent neuropathies similar to those seen in humans. Availability of the experimental animal models has been invaluable to an understanding of the pathogenesis of disease and the development of new treatments.
Document Type: Research Article
Publication date: 1999-12-01
Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.
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