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Open Access Experimental Models of Peripheral Neuropathies

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Abstract:

Background and Purpose: Peripheral neuropathies, disorders of peripheral nerves, result from genetic alterations or from metabolic, inflammatory, infectious, or chemical insults. Experimental animal models, spontaneous or induced, exist for many of the common human peripheral neuropathies. Recent advances in human genetics have led to identification of several specific gene defects involved in heritable neuropathies and have allowed reproduction of the molecular defects in experimental animals.

Methods: Genetic modifications in mice and rats, similar to those seen in humans, along with animal models of specific gene defects are presented and discussed.

Results and Conclusion: Chemotherapeutic agents administered to affected animals mimic the dose-dependent neuropathies similar to those seen in humans. Availability of the experimental animal models has been invaluable to an understanding of the pathogenesis of disease and the development of new treatments.

Document Type: Research Article

Affiliations: 1: Departments of Neurobiology, Stanford University School of Medicine, Stanford, California 2: Comparative Medicine, Stanford University School of Medicine, Stanford, California

Publication date: December 1, 1999

More about this publication?
  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

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