Humoral Immunity and Protection of Mice Challenged with Homotypic or Heterotypic Parvovirus
Methods: Infant mice without maternal antibody or antibody to MVM or MPV and young adult mice given normal mouse serum or antibody to MVM or MPV were challenged with homotypic or heterotypic virus. In situ hybridization with target tissues was the indicator of infection.
Results: Humoral immunity failed to confer protection against acute heterotypic parvovirus infection. In passive transfer studies, MPV DNA was observed occasionally in lymph nodes, intestine, or the spleen of MPVchallenged mice given homotypic antibody and kept for 6 or 28 days. Variable proportions of mice given MPV antibody and homotypic challenge had viral DNA in lymphoid tissues 56 days after virus inoculation.
Conclusion: A mouse or colony that has sustained infection with MVM or MPV is probably fully susceptible to infection with the heterotypic virus.
Document Type: Research Article
Affiliations: 1: Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut 2: Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut, Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut
Publication date: 1999-08-01
Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.
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