Neurons and Mechanisms of Neuronal Death in Neurodegenerative Diseases: A Brief Review
Abstract:Background and Purpose: Degenerative diseases of the central nervous system are a heterogenous group of slowly progressive disorders. A common feature of this group, which includes Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis, is gradual loss of specific populations of neurons.
Methods: A series of reports about neurodegenerative diseases and their relevant animal models, as well as a brief overview of the normal neuron and mechanisms of neuronal degeneration and death, is presented.
Conclusion: Study of the aforementioned animal models, spontaneously occurring and experimentally induced, have provided important insights into the pathogenesis of these disorders and the development of effective therapeutic strategies.
Document Type: Research Article
Affiliations: 1: ZymoGenetics, Seattle, Washington 2: Department of Metabolic Biochemistry, Adolf-Butenandt-Institute, Ludwig-Maximilians-University, Schillerstrasse 44, D-80336 München, Germany 3: Department of Comparative Medicine, School of Medicine, Stanford University, Stanford, California
Publication date: August 1, 1999
Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.
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