Skip to main content

Open Access Auditory Brainstem Responses in Golden Syrian Hamsters (Mesocricetus auratus) Affected with the Wh Gene

Download Article:
 Download
(PDF 222.80078125 kb)
 

Abstract:

Background and Purpose: The anophthalmic white (Wh) gene in Golden Syrian hamsters (Mesocricetus auratus) is autosomal semi-dominant and causes several developmental defects, including hearing loss. The Wh mutation is thought to be homologous to Waardenburg syndrome in humans, apparently affecting similar developmental processes. The purpose of this study was to assess the hearing of hamsters in the AN/As-Wh strain.

Methods: Using auditory brainstem responses, electrophysiologic activity was determined in 20 hamsters of the AN/As-Wh strain, with the aim of elucidating hearing status. Hamsters were classified into five genotypes and were evaluated by use of click stimuli.

Results and Conclusion: Hamsters assigned to the genotypes differed in their hearing sensitivity and could be classified into categories of normal hearing, moderate hearing loss, and profound hearing loss.

Document Type: Research Article

Affiliations: 1: Department of EENT, School of Medical Sciences, University of Science and Technology, Kumasi, Ghana, W. A. 2: Department of Speech and Hearing Sciences, University of North Texas, P.O. Box 305010, Denton, TX 76203-5010 3: Department of Zoology, Michigan State University, East Lansing, Michigan 4: Department of Public Health, Ahwaz Medical School, Ahwaz, Iran 5: Auditory Neuroscience Laboratory, Department of Audiology and Speech Sciences, Michigan State University, East Lansing, Michigan

Publication date: 1999-04-01

More about this publication?
  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

    Attention Members: To access the full text of the articles, be sure you are logged in to the AALAS website.

    Attention: please note, due to a temporary technical problem, reference linking within the content is not available at this time

  • Editorial Board
  • Information for Authors
  • Submit a Paper
  • Subscribe to this Title
  • Membership Information
  • Information for Advertisers
  • For issues prior to 1998
  • Institutional Subscription Activation
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more