Open Access Auditory Brainstem Responses in Golden Syrian Hamsters (Mesocricetus auratus) Affected with the Wh Gene

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Abstract:

Background and Purpose: The anophthalmic white (Wh) gene in Golden Syrian hamsters (Mesocricetus auratus) is autosomal semi-dominant and causes several developmental defects, including hearing loss. The Wh mutation is thought to be homologous to Waardenburg syndrome in humans, apparently affecting similar developmental processes. The purpose of this study was to assess the hearing of hamsters in the AN/As-Wh strain.

Methods: Using auditory brainstem responses, electrophysiologic activity was determined in 20 hamsters of the AN/As-Wh strain, with the aim of elucidating hearing status. Hamsters were classified into five genotypes and were evaluated by use of click stimuli.

Results and Conclusion: Hamsters assigned to the genotypes differed in their hearing sensitivity and could be classified into categories of normal hearing, moderate hearing loss, and profound hearing loss.

Document Type: Research Article

Affiliations: 1: Department of EENT, School of Medical Sciences, University of Science and Technology, Kumasi, Ghana, W. A. 2: Department of Speech and Hearing Sciences, University of North Texas, P.O. Box 305010, Denton, TX 76203-5010 3: Department of Zoology, Michigan State University, East Lansing, Michigan 4: Department of Public Health, Ahwaz Medical School, Ahwaz, Iran 5: Auditory Neuroscience Laboratory, Department of Audiology and Speech Sciences, Michigan State University, East Lansing, Michigan

Publication date: April 1, 1999

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  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

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