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Open Access Selection of the Most Efficacious of Twenty-Two Inactivated Sendai Virus Nasal Vaccines by Determination of the Protection Index in Mice

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Background and Purpose: Sendai virus nasal vaccines inactivated with various chemicals induce complete protection against contact-challenge exposure with the Nagoya strain. The study reported here was to reevaluate the efficacy of the inactivants by determining the protective index (PI) in mice, using the more virulent MN strain.

Methods: Mice were given each of 22 inactivated vaccines intranasally three times. After challenge exposure with 10-2 to 106 MID50 of virus, infection of cells of the respiratory tract was determined by immunofluorescence.

Results: Twelve vaccines induced PI ≥2.0 in the nasal mucosa and were classified as group 1. The first half of the preceding vaccines that induced PI ≥3.2 in the larynx were classified subgroup a, and the rest were classified subgroup b. Of the other 10 vaccines, 6 that induced PI ≤2.0 in the larynx and 4 that induced intermediate PI in the nasal mucosa and larynx were ranked as groups 3 and 2, respectively; PI of the trachea decreased by numeric order of groups. Serum hemagglutination inhibition titer induced by intranasal vaccination was low in general.

Conclusion: On the basis of PI values, 6 of the 22 nasal vaccines provided the strongest defense in the respiratory tract.

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Document Type: Research Article

Affiliations: School of Health Sciences, Fujitagakuen University, Toyoake, Aichi 470-1192, Japan

Publication date: 1999-04-01

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  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

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