Open Access Plasma Electrolyte and Metabolite Concentrations Associated with Pentobarbital or Pentobarbital-Propofol Anesthesia During Three Weeks' Mechanical Ventilation and Intensive Care in Dogs

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Abstract:

Propofol and pentobarbital were used for deep sedation during prolonged mechanical ventilation (3 weeks) and nutritional supplementation in 17 clinically normal dogs in an intensive care setting. Tolerance developed to both drugs. Propofol, in combination with pentobarbital, at an infusion rate of 75 g/kg of body weight per minute was preferred. Pentobarbital infusion alone, begun at the rate of 5 to 6 mg·kg-1·h-1, was satisfactory. The combination of both drugs provided smooth, stable anesthesia and required minimal interventions by intensive care unit personnel. Blood gas tensions and electrolyte, parathyroid hormone (PTH), and metabolite concentrations were generally stable throughout, unless condition of the dog deteriorated (e.g., infection, pneumothorax). Hematocrit and red blood cell count decreased with time, likely attributable principally to multiple blood sample collections. White blood cell count, alkaline phosphatase, phosphate, fibrinogen, cholesterol, and triglyceride values increased with time, in association with pentobarbital and the combination of pentobarbital and propofol. Some of these changes appear to have been related to generic responses to stress and inflammation, some to altered metabolism, and some to the lipid solvent of propofol. The increase in triglyceride concentration was greater when propofol was used. Mortality was 47%, with death occurring between days 2 and 18.

Document Type: Research Article

Affiliations: 1: Department of Anesthesiology, School of Medicine, University of California, MED: Anesthesiology, TB 170, Davis, CA 95616 2: Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, California 3: Department of Anesthesiology, School of Medicine, University of California, Davis, California

Publication date: October 1, 1998

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  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

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