Morphologic and Hematologic Characteristics of Storage Pool Deficiency in Beige Rats (Chédiak-Higashi Syndrome of Rats)
Abstract:Characterization of beige rats as having a platelet storage pool deficiency (SPD) was undertaken. Platelets from beige rats, an animal model of Chédiak-Higashi syndrome (CHS), completely lacked the ability to aggregate when stimulated with high dosages of collagen (50 g/ml), and lacked secondary aggregation induced by adenosine diphosphate (ADP). Concentrations of ADP, ATP, and serotonin in the platelets of beige rats were significantly lower than those of control rats. However, platelet count remained within normal values. Electron microscopy revealed that platelets had fewer dense granules, whereas other organelles had normal structure. This morphologic and functional evidence confirms that platelets of beige rats have the typical characteristics of SPD.
Document Type: Research Article
Affiliations: 1: Research Institute of Drug Safety, Setsunan University, 45-1 Nagaotohge-cho, Hirakata, Osaka 573-0101, Japan 2: Department of Analytical Chemistry in Hygiene, Setsunan University, Osaka, Japan 3: Faculty of Pharmaceutical Science, Setsunan University, Osaka, Japan; First Department of Internal Medicine, Kansai Medical University, Osaka, Japan 4: Institute of Experimental Animals, Hamamatsu University Schoolof Medicine, Shizuoka, Japan 5: Research Institute of Drug Safety, Setsunan University, Osaka, Japan
Publication date: October 1, 1998
Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.
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