Skip to main content

Open Access Morphologic and Hematologic Characteristics of Storage Pool Deficiency in Beige Rats (Chédiak-Higashi Syndrome of Rats)

Download Article:
(PDF 175.8046875 kb)
Characterization of beige rats as having a platelet storage pool deficiency (SPD) was undertaken. Platelets from beige rats, an animal model of Chédiak-Higashi syndrome (CHS), completely lacked the ability to aggregate when stimulated with high dosages of collagen (50 g/ml), and lacked secondary aggregation induced by adenosine diphosphate (ADP). Concentrations of ADP, ATP, and serotonin in the platelets of beige rats were significantly lower than those of control rats. However, platelet count remained within normal values. Electron microscopy revealed that platelets had fewer dense granules, whereas other organelles had normal structure. This morphologic and functional evidence confirms that platelets of beige rats have the typical characteristics of SPD.

31 References.

No Supplementary Data.
No Data/Media
No Metrics

Document Type: Research Article

Affiliations: 1: Research Institute of Drug Safety, Setsunan University, 45-1 Nagaotohge-cho, Hirakata, Osaka 573-0101, Japan 2: Department of Analytical Chemistry in Hygiene, Setsunan University, Osaka, Japan 3: Faculty of Pharmaceutical Science, Setsunan University, Osaka, Japan; First Department of Internal Medicine, Kansai Medical University, Osaka, Japan 4: Institute of Experimental Animals, Hamamatsu University Schoolof Medicine, Shizuoka, Japan 5: Research Institute of Drug Safety, Setsunan University, Osaka, Japan

Publication date: 1998-10-01

More about this publication?
  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

    Attention Members: To access the full text of the articles, be sure you are logged in to the AALAS website.

    Attention: please note, due to a temporary technical problem, reference linking within the content is not available at this time

  • Editorial Board
  • Information for Authors
  • Submit a Paper
  • Subscribe to this Title
  • Membership Information
  • Information for Advertisers
  • For issues prior to 1998
  • Institutional Subscription Activation
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more