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Open Access Model of Emotional Stress in Rats

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A new experimental rat model for suppression of release of arginine vasopressin (AVP) was evaluated. Release of AVP is potentiated by physiologic stimuli, but is suppressed by emotional stress. Rats were exposed to the aggressive behavior of other rats injected with 6-hydroxydopamine hydrochloride (6-OHDA) in both lateral ventricles and subjected to a pain stimulus applied to the tail. To ascertain whether emotional stress is induced by use of this method, plasma corticosterone, glucose, and AVP concentrations were measured in the stressed group of rats (n = 8) placed near a group of aggressive (fighting) rats. Characteristic changes in behavior, significant increases in plasma corticosterone and glucose values, and lack of increase in plasma AVP concentration in stressed rats confirmed that they experienced emotional stress. This new model meets the experimental requirements for suppression of AVP release in rats.

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Document Type: Research Article

Affiliations: 1: Laboratory of Pathophysiology, National Institute of Animal Health, 3-1-1 Kannondai, Tsukuba-shi, Ibaraki 305 2: Imamichi Institute for Animal Reproduction, Dejima, Ibaraki 300-01, Japan 3: Department of Veterinary Internal Medicine, Nippon Veterinary and Animal Science University, 1-7-1 Kyounann-cho, Musashino-shi, Tokyo 180

Publication date: 1998-08-01

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  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

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