Hypothermia Reduces Neurologic Deficits Associated with Placement of a Vascular Prosthesis in the Abdominal Aorta of Rabbits
Abstract:Treatment for atherosclerotic vascular disease in human beings ranges from medical management to interventional therapy, such as angioplasty, atherectomy, and bypass grafting. Recently, bypass grafting with a vascular prosthesis has received increased attention and clinical use. In the course of studies to optimize use of a small-caliber vascular prosthesis, five of six rabbits undergoing implantation of a polytetrafluoroethylene vascular prosthesis in the infrarenal abdominal aorta developed hind limb neurologic deficits, which resulted from focal ischemic damage to the spinal cord attributable to temporary vascular occlusion of the abdominal aorta during placement of the vascular prosthesis. In subsequent studies, induction of systemic hypothermia decreased the rate of development of neurologic deficits from 83 to 9% without any apparent perioperative complications associated with decreased body temperature. We determined that mild hypothermia (rectal temperature of 32 to 35°C), combined with aortic occlusion time of <40 min, is sufficient to afford protection from ischemic injury to the spinal cord in the rabbit.
Document Type: Research Article
Affiliations: 1: Department of Comparative Medicine, Stanford University School of Medicine, RAF-1, Quad7, Building 330, Stanford, CA 94305-5410 2: Department of Medicine, Stanford University, Stanford, California, First Department of Surgery, Yokohama City University School of Medicine, 2-9 Fukuura Kanazawa-ku, Yokohama, 236 Japan 3: Department of Comparative Medicine, Stanford University, Stanford, California, ZymoGenetics, 1201 Eastlake Avenue East, Seattle, WA 98102 4: Department of Comparative Medicine, Stanford University, Stanford, California 5: Department of Statistics, Stanford University, Stanford, California 6: Department of Medicine, Stanford University, Stanford, California, Laboratory of Genetic Physiology, Brigham and Women's Hospital, 75 Francis Street, Thorn-13, Boston, MA 02115
Publication date: 1998-06-01
Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.
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