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Open Access Effect of Feeding of a Cholesterol-Reducing Bacterium, Eubacterium coprostanoligenes, to Germ-Free Mice

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Twelve germ-free mice were used to evaluate the effect of orally administered Eubacterium coprostanoligenes (ATCC 51222) on serum cholesterol concentration. After 1 week of bacterial administration, serum cholesterol concentration of the experimental group (204.9 ± 5.3 mg/dl, mean ± SEM) tended to be lower than that of controls (213.7 ± 5.9 mg/dl, mean ± SEM). The hypocholesterolemic effect, however, was transient. Greater coprostanol-to-cholesterol ratios in feces of bacteria-fed mice also indicated a transient cholesterol-reducing action of E. coprostanoligenes in the intestine. Eubacterium coprostanoligenes did not colonize the intestine of E. coprostanoligenes-fed mice. Results indicate that the transient occurrence of E. coprostanoligenes in the digestive tract of E. coprostanoligenes-fed mice may decrease plasma cholesterol concentration, but colonization of the tract depends on monoassociation with another bacterium. Results also indicate that feeding of E. coprostanoligenes decreases blood cholesterol concentration.

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Document Type: Research Article

Affiliations: 1: Department of Animal Science, Iowa State University, Ames, Iowa 2: Department of Microbiology, Immunology, and Preventive Medicine, Iowa State University, Ames, Iowa 3: Department of Animal Science, 313 Kildee Hall, Iowa State University, Ames, IA 50011-3150

Publication date: 1998-06-01

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  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

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