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Open Access Absence of a Significant Mixed Lymphocyte Reaction in a Marsupial (Monodelphis domestica)

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Previously we reported preliminary results suggesting that the marsupial Monodelphis domestica fails to exhibit a mixed lymphocyte reaction with allogeneic lymphocytes. To test whether this observation is simply a matter of a response too weak to detect, but capable of being augmented by immunization, we performed mixed lymphocyte culture tests on 23 of these animals that had been immunized with lymphocytes. Despite the fact that all recipients were sensitized to the lymphocytes of the donors, none of the animals had a substantial mixed lymphocyte response. Significant stimulation was noted with the mitogen concanavalin A; thus, the T cells were immunologically competent. It seems likely that the failure of this species to exhibit a significant mixed lymphocyte response is due to T cells whose ontogeny differs from that of the T cells of eutherian mammals.

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Document Type: Research Article

Affiliations: 1: Department of Biology, Trinity University, 715 Stadium Drive, San Antonio, TX 78212-7200 2: Department of Biology, Trinity University 3: Department of Mathematics, Trinity University 4: Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 5: Department of Pediatrics, University of Texas Health Science Center, San Antonio, Texas

Publication date: 1998-04-01

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  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

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