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Open Access Effects of Feeding a Liquid Diet for One Year to New Zealand White Rabbits

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We compared the long-term effects of a newly designed liquid diet with a commercially available dry diet in New Zealand White rabbits. Body weight gain, feed consumption, and plasma lipid concentrations were measured periodically throughout the 1-year study. In addition, specific hepatic enzyme activities in serum were quantified to examine the effects of liquid diet on the liver over the 1-year feeding trial. At 52 weeks, body weight gains between the liquid- and dry-fed groups were similar. Regardless of sex, plasma phospholipid concentrations were higher in the control group than in the liquid-fed group. Plasma triglyceride concentrations were increased in liquid-fed female rabbits, compared with either male group or control-fed females. A somewhat similar effect was observed in plasma cholesterol concentration, which was higher in female rabbits regardless of diet type. After the 52-week trial, the rabbits had no clinical biochemical signs of liver damage. Results of this study indicate that a liquid diet can be fed to New Zealand White rabbits for a long period, and may provide an alternative route (food source) for future pathophysiologic studies.

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Document Type: Research Article

Affiliations: 1: Department of Animal Sciences, Purdue University, 1151 Lilly Hall, West Lafayette, IN 47907-1151 2: West Lafayette, Indiana; Purina Mills Inc., St. Louis, Missouri 3: Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri

Publication date: 1998-02-01

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  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

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