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Open Access Animal Model of Uterine Adenomyosis: Induction of the Lesion in Rats by Ectopic Pituitary Isografting

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Adenomyosis is a benign pathologic disorder of the uterine endometrial tissues whereby endometrial components, such as glands and stroma, invade the myometrium. Transplantation of a single anterior pituitary gland into the uterine lumen induced adenomyosis in six of eight Wistar rats 12 months after the grafting. Adenomyotic changes were not observed in six sham-operated control rats. Electron microscopic observations indicated that cells of the inner layer of the myometrium were reduced in size and irregularly shaped in the areas bearing adenomyotic changes. In pituitary-grafted rats, healthy corpora lutea remained in the ovaries, whereas control rats had degenerating ovaries. These findings are consistent with the results of pituitary-grafted mice reported previously and support our assertion that a hormonal milieu induced by pituitary grafting is favorable for development of uterine adenomyosis.

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Document Type: Research Article

Affiliations: 1: Department of Biological Sciences, Graduate School of Science, University of Tokyo, Bunkyo-ku, Tokyo 113, Japan 2: Experimental Animal Research Laboratory, Meiji University, Kawasaki 214-71, Japan

Publication date: 1998-02-01

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  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

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