@article {Malkin:1998:1532-0820:48,
title = "Improved Guinea Pig Model of Cardiac Tachyarrhythmias",
journal = "Comparative Medicine",
parent_itemid = "infobike://aalas/cm",
publishercode ="aalas",
year = "1998",
volume = "48",
number = "1",
publication date ="1998-02-01T00:00:00",
pages = "48-53",
itemtype = "ARTICLE",
issn = "1532-0820",
eissn = "2769-819X",
url = "https://www.ingentaconnect.com/content/aalas/cm/1998/00000048/00000001/art00008",
author = "Malkin, Robert A and Eynard, Jean-Noel and Pergola, Nicholas F.",
abstract = "Guinea pigs are frequently used as models for ventricular tachyarrhythmias, including polymorphic ventricular tachycardia (VT) and ventricular fibrillation. However, applications of the model for shortterm therapies are limited because the arrhythmias are transient, typically lasting 800 g), the efficacy of an established short-term therapy for tachyarrhythmias was measured, using the proposed rapid pacing model. All arrhythmias induced by use of the three induction methods were polymorphic VT accompanied by complete hemodynamic collapse. In hearts weighing >2.5 g (body mass >800 g), 100% of arrhythmia episodes were sustained for 30 sec or longer when initiated after rapid pacing, as opposed to only 55% sustained by use of other induction methods (P < 0.01). The efficacy results for the established shortterm therapy matched those previously reported for 100-kg calves. A brief period of rapid pacing facilitates initiation of consistent, sustained ventricular tachyarrhythmias in large guinea pigs, eliminating spontaneous termination as a confounding factor in the study of short-term therapies.",
}