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Open Access Epizootic of Group B Streptococcus agalactiae Serotype V in DBA/2 Mice

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Beta-hemolytic Streptococcus agalactiae serotype V was identified as the cause of an infection in laboratory mice. Principally, the organism induced fatal septicemia in DBA/2 breeding-age mice. The syndrome appeared to originate as an ascending pyelonephritis, which progressed to septicemia. Microscopic lesions were found in the heart, kidneys, spleen, and liver, and less commonly in the uterus, thoracic cavity, lymph nodes, and lungs. The epizootic was controlled by eradication of the breeding colonies, disinfection of the barrier, and autoclaving of all equipment. The new replacement colonies have remained free of the organism.

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Document Type: Research Article

Affiliations: 1: Taconic, 273 Hover Avenue, Germantown, NY 12526 2: AnMed/BioSafe, Rockville, Maryland 3: Taconic, Germantown, New York

Publication date: 01 February 1998

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  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

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