If you are experiencing problems downloading PDF or HTML fulltext, our helpdesk recommend clearing your browser cache and trying again. If you need help in clearing your cache, please click here . Still need help? Email help@ingentaconnect.com

Open Access Anthelmintic Treatment to Eradicate Cutaneous Capillariasis in a Colony of South African Clawed Frogs (Xenopus laevis)

 Download
(PDF 113.2kb)
 
Download Article:

Abstract:

The nematode Capillaria xenopodis (Pseudocapillaroides xenopi), a skin parasite of South African clawed frogs (Xenopus laevis), is quite common in laboratory animal facilities. It causes serious skin changes and may further lead to wasting and death of affected frogs. Various treatment protocols, using the anthelmintics ivermectin and levamisole, were successively tested for practicability of elimination of the parasite from a colony of clawed frogs. Nematodes were reduced below diagnostic levels by various methods of application of ivermectin (orally or by injection into the dorsal lymph sac, twice at intervals of 10 to 14 days). However, nematodes were found again in the treated animals 1 to 3 months later. Treatment by use of ivermectin-medicated tank water is not feasible due to its low water solubility. Elimination of the parasite was reliably achieved by use of levamisole-medicated tank water. Relapses were not seen during the 18-month posttreatment observation period. Levamisole concentration was 12 mg/L of water, with 4.17, 5.00, or 6.25 L of tank water/frog, and 50, 60, or 75 mg of levamisole available/frog, for at least 4 days, with treatments repeated after 10 to 14 days. Results were reproducible in two trials each with five tanks containing, in turn, four or five frogs each. A treatment trial carried out with a group of 20 adult frogs exposed to 12 mg of levamisole/L of tank water, but with only 2.5 L of tank water/frog (i.e., only 30 mg of levamisole available/animal), was not effective in eradicating the parasites. Not only the drug concentration, but also the amount of drug available per animal seems to be of importance. In contrast to thiabendazole, which is often reported in literature as treatment for cutaneous capillariasis, negative side effects were not observed with use of levamisole.

Document Type: Research Article

Publication date: October 1, 1997

More about this publication?
  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

    Attention Members: To access the full text of the articles, be sure you are logged in to the AALAS website.

    Attention: please note, due to a temporary technical problem, reference linking within the content is not available at this time
  • Editorial Board
  • Information for Authors
  • Submit a Paper
  • Subscribe to this Title
  • Membership Information
  • Information for Advertisers
  • For issues prior to 1998
  • Institutional Subscription Activation
  • ingentaconnect is not responsible for the content or availability of external websites
Related content

Tools

Favourites

Share Content

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more