Enzymatic Oxidation of 1,4- and 1,8-Cineole using Plant Cultured Cells of Catharanthus Roseus
Oxidases present in plant cultured cells of Catharanthus roseus can hydroxylate saturated centers of natural products without double bond activation. When starting materials were 1,8- or 1,4-cineole, secondary and tertiary alcohols were produced and identified using NMR and mass spectroscopy. Our results indicate that hydroxylation position and stereochemistry are determined by the biotransformation organism.
Keywords: 1,8-cineole; biotransformation organism; catharanthus roseus
Document Type: Review Article
Affiliations: Department of Applied Science, Okayama University of Science, 1-1 Ridai-cho, Okayama 700- 0005, Japan.
Publication date: 01 April 2004
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